The metacaspase Yca1 maintains proteostasis through multiple interactions with the ubiquitin system
نویسندگان
چکیده
منابع مشابه
Metacaspase Yca1 is required for clearance of insoluble protein aggregates.
In complex organisms, caspase proteases mediate a variety of cell behaviors, including proliferation, differentiation, and programmed cell death/apoptosis. Structural homologs to the caspase family (termed metacaspases) engage apoptosis in single-cell eukaryotes, yet the molecular mechanisms that contribute to nondeath roles are currently undefined. Here, we report an unexpected role for the Sa...
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ژورنال
عنوان ژورنال: Cell Discovery
سال: 2019
ISSN: 2056-5968
DOI: 10.1038/s41421-018-0071-9